Nicotine is a vasoconstrictor that reduces nutritional blood flow to the skin, resulting in tissue ischemia and impaired healing of injured tissue.
What does smoking do to skin?
When you vape, nicotine impedes blood flow, which slows wound healing. One study demonstrated that vaping slowed that healing after surgery—an extreme example of why nicotine isn’t good for skin health at any time.
Nicotine also increases platelet adhesiveness, raising the risk of thrombotic microvascular occlusion and tissue ischemia.

How nicotine harms our skin
The nicotine in vaping liquids dehydrates your skin,” explains Dr. Raja. “So you can get premature wrinkles and very dry skin, which don’t look good. In addition to skin aging, too, vaping can also delay wound healing.
Nicotine and Wrinkles
Crow’s feet are a common type of wrinkling that develops at the outer edges of the eyes. For smokers, this damage usually starts much earlier than it does for other people, who get crow’s feet as they age.
Smoking-related skin damage can cause sagging skin in other parts of the body. In particular, breasts and upper arms are often affected by the loss of skin elasticity due to smoking.
Psoriasis is a skin condition that produces itchy, red scaly patches. Stress can bring it on, but smoking is also a risk factor.
Doctors think that the link between the disease and smoking may be the nicotine in cigarettes. Nicotine affects the immune system, skin inflammation, and skin cell growth, all of which can contribute to the development of psoriasis.
Smoking just about doubles a person’s risk of developing psoriasis, with the risk going up depending on the number of cigarettes smoked.
Nicotine and acne
acne inversa, is a relatively common inflammatory skin disease that affects people in areas of the body where skin rubs against skin, like the armpits, groin, and under the breasts in women.
Does nicotine affect the skin tone?
The skin tone of smokers can be uneven and off, tending toward an orange or grey tone. Lack of oxygen to skin cells no doubt plays a part in why this occurs, along with the negative effects of numerous other chemicals in tobacco.
Cigarette smoke is laden with over 7,000 chemicals, including 250 that are poisonous and 70 that cause cancer.

Does nicotine reduce collagen?
Collagen and elastin production will assist in that as well, as they’re no longer being hindered by toxins in cigarettes. Smokers tend to have wrinkles around the mouth, upper lip, and eyes, darker skin, less radiance, and less tightness overall in their skin. smoking doesn’t just increase the toxic load on our skin. It also eats away at stores of the stuff that actively improves our skin. In this case, we’re talking collagen.
Nicotine inhibits collagen synthesis and alkaline phosphatase activity, but stimulates DNA synthesis in osteoblast-like cells. … This study was performed to test the effects of nicotine on bone-forming cells at concentrations that occur in the saliva of smokeless tobacco users.
- Impaired collagen production
- Fibroblasts (the collagen production factories) are inhibited by nicotine.
- Lower levels of vitamin C are found in smokers’ tissue. Vitamin C is vital to the assembly of new collagen.
